A significant correlation between the WWP2-positive area and fibrosis in the tubulointerstitial region was detected in a multicenter cohort of patients with CKD (r=0.274, P = 0.001, Figure 1C) and confirmed in two cohorts of patients with IgA nephropathy (Supplemental Figure 1B). The gene discussed is WWP2; the disease is IgA glomerulonephritis.