We previously identified the homologous to E6AP C-terminus domain E3 ubiquitin–protein ligase WWP2 as a regulator of myofibroblast profibrotic activation in cardiac fibrosis.28 Giving the widespread tissue expression and master regulatory role of WWP2 in orchestrating profibrotic ECM network,28,29 we hypothesized that WWP2 regulates myofibroblast phenotypes and tissue fibrosis in kidney disease. This evidence concerns the gene WWP2 and kidney disorder.