PPARGC1A and renal fibrosis: Given the regulatory role of WWP2 in fatty acid oxidation during murine and human renal fibrosis, we focused on PGC-1α, a critical modulator of fatty acid oxidation25,26 and of metabolism during tissue fibrosis.71, –73 To investigate the transcriptional regulation of PGC-1α by WWP2, we first used ChIP-seq analysis and assessed WWP2 binding to the Ppargc1a locus, which encodes for PGC-1α (Figure 6A).