CD8A and metastatic malignant neoplasm in the lymph nodes: Patients with high LLT1TC expression and low CD161 expression in CD8+ T cells in situ had a higher risk of lymph node metastasis (Figure 5B) and shorter OS, MFS, and DFS (all p < 0.0001; Figure 5C) with reduced circulating T cells in the blood (Figure 5D).