As illustrated in Figure 1, ALKBH5 exhibits significant overexpression in a majority of tumor tissues when compared to their neighboring normal tissues, including breast invasive carcinoma (BRCA), adrenocortical carcinoma (ACC), cholangiocarcinoma (CHOL), HCC, etc. This pattern of differential expression implies a potential role of ALKBH5 in the oncogenesis and progression of these tumor types, warranting further investigation into its mechanistic contributions. Here, ALKBH5 is linked to cholangiocarcinoma.