Among them, TTI1 has the highest correlation with ALKBH5 (r ═ 0.46), followed by ADNP (r ═ 0.39) and ACIN1 (r ═ 0.36), therefore, we identified TTI1 as the key downstream gene of ALKBH5. TTI1 expression was shown to be considerably greater in HCC tumors than in normal tissues (Figure 7D). The gene discussed is ACIN1; the disease is hepatocellular carcinoma.