Irgm1−/− mice display numerous phenotypes that parallel these inflammatory associations of human IRGM, including an increased susceptibility to intestinal inflammation in multiple models, a Sjogren’s syndrome-like autoimmune phenotype underlined by a type I interferonopathy, and a defect in resistance to mycobacterial infection (41, –, 44, 47, 63, 64). This evidence concerns the gene IRGM and inflammatory response.