However, our findings in genital Chlamydia infection along with recent studies demonstrating that pan-Irgm−/− mice display altered cytokine profiles and worsened mortality in Mycobacterium tuberculosis infection (53) highlight the possibility that a failure in human IRGM-mediated disease tolerance also contributes to the observed increase in mycobacterial disease in susceptible individuals. Here, IRGM is linked to chlamydia infectious disease.