One study found that PDAC cells reprogrammed macrophages from M1‐like macrophages to M2‐like macrophages, followed by increased secretion of the cytokine IL‐10, which interacted with receptors on the surface of tumour cells and activated IL‐10/IL‐10R‐downstream signalling in tumour cells, promoting their metastasis.41 This evidence concerns the gene IL10RA and neoplasm.