High plasma and kidney renin activity18,19 and abnormalities of renal glomerular haemodynamics are seen during the development of SHR hypertension.44 Our previous cross-breeding studies have genetically linked BP, glomerular haemodynamics, and plasma renin activity to the development of hypertension.20 The involvement of kidney renin with the legacy effect also aligns with two other important observations. The gene discussed is REN; the disease is Hypertension.