Fortunellin attenuated lipopolysaccharide (LPS)‐stimulated acute lung injury (ALI) through repressing the Toll‐like receptor 4 (TLR4)/nuclear factor kappa‐B (NF‐κB)/NLR Family Pyrin Domain Containing 3 (NLRP3) pathway. This evidence concerns the gene TLR4 and acute respiratory distress syndrome.