KHSRP–SIRT7 interaction is attenuated upon androgen receptor (AR) activation in PCa cells, which leads to acetylated KHSRP inefficiently reaching the adenine uridine (AU)‐rich elements (AREs) in the 3′‐UTR of DDR genes to exert mRNA decay function. This evidence concerns the gene KHSRP and posterior cortical atrophy.