The findings of our pooled analysis suggested that the higher density of total CD68+ TAMs infiltration in the tumor indicated poor OS and DFS, while greater CD163+ and CD204+ TAMs density suggested worse prognosis in ESCC patients underwent surgery, Moreover, a high CD68+ TAMs density was closely link to lymphatic vessel invasion, vascular invasion, and lymph node metastasis. The gene discussed is MSR1; the disease is neoplasm.