The findings of our pooled analysis suggested that the higher density of total CD68+ TAMs infiltration in the tumor indicated poor OS and DFS, while greater CD163+ and CD204+ TAMs density suggested worse prognosis in ESCC patients underwent surgery, Moreover, a high CD68+ TAMs density was closely link to lymphatic vessel invasion, vascular invasion, and lymph node metastasis. Here, CD68 is linked to metastatic malignant neoplasm in the lymph nodes.