To address the trans-species pathogenicity transduction potential by EVs derived from patients with BMD and DMD in the in vivo context of a whole animal, we isolated EVs from the serum of patients and applied them to a model organism that could potentially develop muscular dystrophy but does not carry genetic mutations in the dystrophin gene, which is the direct genetic cause of this disease. The gene discussed is DMD; the disease is Duchenne muscular dystrophy.