These changes in expression were consistent with the previous changes, suggesting that both high-dose fish oil and olive oil diets have ameliorative effects on hyperlipidemia and insulin sensitivity in the context of HFD-induced obesity, while olive oil rich diet showed such advantage in maintaining the physiological function of pancreatic islets (Figures 5G, H). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.