MAPT and Mental deterioration: This observation suggests that the accelerated cognitive decline in individuals with impaired olfaction could potentially be attributed to pathologies related to aging, such as amyloid beta, tau, or cholinergic dysfunction, which is possibly exacerbated by underlying Lewy pathology (Tsuboi et al., 2003; Mundiñano et al., 2011; Fullard et al., 2016; Pasquini et al., 2021; Borghammer et al., 2022).