Contrary to the previously mentioned circRNAs, elevated levels of circNDUFB2 inhibit tumor growth and metastasis in NSCLC cells by acting as a scaffold to enhance the interaction between the TRIM25 (Tripartite Motif Containing 25) and IGFBP2 (Insulin like Growth Factor Binding Protein 2) genes. The gene discussed is IGFBP2; the disease is neoplasm.