The TGF-β is highly expressed in NSCLCs and it promotes EMT and NSCLC cell invasion, whereas TIFγ acts as a tumor metastasis suppressor by regulating TGF-β/Smad signaling pathway (Dupont et al., 2005; Zhang et al., 2011; Xue et al., 2014). The gene discussed is TGFB1; the disease is non-small cell lung carcinoma.