Additionally, circNDUFB2 is recognized by RIG-I (Retinoic acid-Inducible Gene I) and leads to activation of the RIG-I-MAVS (Mitochondrial Antiviral Signaling protein) signaling cascade, with consequent immune cell recruitment into the tumor microenvironment (TME) (Li et al., 2021). The gene discussed is MAVS; the disease is neoplasm.