TLR7 and systemic lupus erythematosus: With this, it has been recently found that two TLR7 variants (Y264H and F507L) were recently identified to cause SLE, with the Y264H variant presenting with an increased sensing of guanosine and 2′,3′-cGMP (Shibata et al., 2016; Zhang et al., 2016; Zhang et al., 2018; Brown et al., 2022).