With this framework for variant interpretation and genomic data from various consortia, this can be potentially applied to the dysmorphic syndromes associated with SLE, specifically genes of the Ras/mitogen-activated protein kinase (Ras/MAPK) pathway to identify with greater certainty the potential pathogenic genetic variants within this pathway that contribute to SLE (Amoroso et al., 2003; Lisbona et al., 2009; Leventopoulos et al., 2010; Hanaya et al., 2017; Uehara et al., 2018). This evidence concerns the gene WNK2 and systemic lupus erythematosus.