TLR7 and systemic lupus erythematosus: Lastly, defects in nucleic acid sensing and degradation genes DNASE1 (Yasutomo et al., 2001; Almlof et al., 2019), DNASE1L3 (Al-Mayouf et al., 2011; Almlof et al., 2019) and TLR7 (Giltiay et al., 2013; Brown et al., 2022) have been found in SLE patients.