DSS-induced colitis is aggravated in Reg3β KO mice relative to wild-type mice, suggesting that attenuation of colitis and ileitis is dependent on the function of Reg3β (Shindo et al., 2020) miRNA knockdown of Reg3β and Reg3γ promotes colitis in mice (Runtsch et al., 2015). The gene discussed is REG3G; the disease is Crohn ileitis.