BRCA1 and lobular breast carcinoma in situ: The Gail risk score calculator is not recommended for women with a BRCA1 or BRCA1 mutation, previous history of lobular carcinoma in situ (LCIS) or ductal carcinoma in situ (DCIS), women with Li-Fraumeni mutation, or those who have had radiation therapy to the chest [8,9]. Referral to a medical geneticist is recommended for Li-Fraumeni syndrome and other inherited causes [8].