For clinical decision-making, it is recommended to use mainly biochemical markers such as elevated levels of D-dimer, CRP, LDH, troponin, ferritin, and CK, as well as a decrease in absolute lymphocyte counts and an increase of NLR, as indicators of COVID-19 severity [[11], [12], [13], [14], [15], [16]]. The gene discussed is CRP; the disease is COVID-19.