It has been recommended that constipation springing up more than 10 years prior to the onset of cardinal motor symptoms, even up to 20 years prior is associated with a high prevalence, sustained risk of PD. Accumulation of α-synuclein and other neurodegenerative adjustments in the autonomic nervous system has been associated with the denervation of the myenteric plexus of the colonic sympathetic innervation [4]. This evidence concerns the gene SNCA and Parkinson disease.