Interestingly, a pattern of ‘coexisting suppression and activation’ may explain the loss of CD4+ T cells and inversed CD4/CD8 ratio during COVID-19, and the further exaggeration of this trend in ASyS patients may indicate a shared pathology involving dysregulated lymphocyte proliferation, apoptosis, or tissue chemotaxis of certain pathological lymphocyte subsets (32). Here, CD4 is linked to COVID-19.