In particular, certain myositis-specific antibodies (MSAs)-gauged subtypes of IIM, e.g., anti-synthetase syndrome (ASyS) and anti-melanoma differentiation-associated gene 5 (MDA5) positive dermatomyositis (DM), are more frequently complicated with significant ILD (12, 13). Here, IFIH1 is linked to acquired idiopathic inflammatory myopathy.