Tumor-infiltrating eTregs are activated and possess robust immunosuppressive properties (52), with high expression of molecules like CD25, CTLA4, PD-1, ICOS, LAG-3, TIGIT, and members of the TNF receptor superfamily, like GITR, 4-1BB, and OX-40 (53). The gene discussed is LAG3; the disease is neoplasm.