GZMB and Hodgkins lymphoma: While in classical Hodgkin lymphoma tissues, the expression of FOXP3 alone may not serve as an independent prognostic factor, a multivariate analysis model including FOXP3, PD-1, and granzyme B demonstrates certain predictive value for the prognosis of classical Hodgkin lymphoma patients, with higher levels of FOXP3 expression often correlating with longer overall survival (50).