This study aimed to investigate the effects of TNF-alpha inhibitors on lipid profiles (triglycerides, total cholesterol, low-density lipoprotein, or high-density lipoprotein) in patients with psoriasis.<h4>Methods</h4>We searched PubMed, Embase, and Cochrane Library databases for articles published before October 17, 2023. The gene discussed is TNF; the disease is psoriasis.