ITGAM and atherosclerosis: Likewise in the adeno-associated virus PCSK9 mouse model of atherosclerosis, whilst the dysregulation of BM haematopoiesis in B cell-ChAT-deficient mice was reflected by higher levels of CD11b+ myeloid cells, Ly6G+ neutrophils, Ly6Chi monocytes and F4/80+ macrophages in the aorta and increased lesion size, relative to their control counterparts, the authors also found recruitment of ChAT+ B cells to the aorta plaques (46).