IL10 and Autoimmunity: Specifically, the ES-62-driven protection against each of CIA-induced intestinal barrier pathology and inflammation, autoimmunity (e.g., its reduction of pathogenic anti-type II collagen IgG2a antibodies, serum IL-6 levels and restoration of IL-10-producing Breg cells), osteoclastogenesis and joint pathology, can be seen to require an intact gut microbiome (7).