Perhaps reflecting these protective actions of ES-62, whilst linear regression analysis of the mice in this study showed a clear inverse relationship between the levels of both B220+ and CD3+ cells in the BM of CIA mice and joint disease severity (Figures 4E, F), no significant correlation was found between articular score and any of the myeloid lineages tested (Figures 4G-I). The gene discussed is PTPRC; the disease is arthropathy.