Moreover, the ability of parasitic helminth-derived immunomodulator, ES-62 to reset immunoregulation (by restoring levels of IL-10-producing regulatory B cells [Bregs]) and exert its protection against Th1/Th17-driven autoimmunity and resultant joint pathology in the CIA model of RA, is lost following microbiome depletion (7). This evidence concerns the gene IL10 and rheumatoid arthritis.