NFE2L2 and neoplasm: The correlation of increased NRF2 activation with tumor progression and aggressiveness has been thoroughly reviewed by Choi et al. (Choi, Kim, and Kwak, 2021) For example, NRF2 status was significantly associated with histological grade of breast cancer (Onodera et al., 2014) or its expression correlates with the progression of gastric cancer (Kawasaki et al., 2015).