Increased oxidative stress and decreased mitochondrial membrane potential were also observed in in vitro and in vivo HER-2 negative BC models for the following extracts: the common hibiscus (Hibiscus rosa-sinensis L., Malvaceae) (Nguyen et al., 2019), sea daffodil (Pancratium maritimum L., Amaryllidaceae) (Sancha et al., 2022), lichen Parmotrema rampoddense (Nyl). This evidence concerns the gene ERBB2 and breast cancer.