The compatibility of CF with aconitums can regulate the levels of FKBP1B and RyR2 genes in sarcoplasmic reticulum by affecting TRP gene, especially TRPM8, so as to protect myocardium from damage and play a role in reducing toxicity (Meng et al., 2023). The gene discussed is FKBP1B; the disease is cystic fibrosis.