TF and glioblastoma: Multiple studies have indicated that endogenous Tf, as a targeting molecule for liposome transport, has various therapeutic effects, including improvement after stroke and brain injury (Omori et al., 2003; Reddy et al., 2006), treatment of glioblastoma multiforme (GBM) tumors (Jhaveri et al., 2018; Lakkadwala and Singh, 2019), and gene silencing after siRNA delivery into the brain (Cardoso et al., 2010).