Exploring L5's role in ventricular tachyarrhythmias, we previously demonstrated that L5 might directly modulate the electrophysiological properties by altering sarcolemmal ionic currents through LOX-1 signaling in ventricular cardiomyocytes, according to in vivo and in vitro experiments, which could provide insight into a potential role of L5 in early VT/VF occurrence in STEMI patients (29). The gene discussed is OLR1; the disease is ST Elevation Myocardial Infarction.