SOD1 and amyotrophic lateral sclerosis: The UAS/Gal4/Gal80 system can upregulate and knock down D. melanogaster genes, including SOD1, and the ectopic expression of human SOD1 genes or mutations in a tissue-specific manner, exhibiting the typical pathologies of hmSOD1 ALS, which is beneficial for further investigation to identify disease-modifying genes, mutations, and disease pathways (Walters et al., 2019).