TARDBP and proteostasis deficiencies: TDP-43 D. melanogaster models revealed that the mechanisms of toxic GOF are related to TDP-43 proteinopathy (Lu et al., 2009; Elden et al., 2010; Hanson et al., 2010; Li et al., 2010; Ritson et al., 2010; Voigt et al., 2010; Estes et al., 2011; Miguel et al., 2011).