It is currently understood that the neurodegenerative disease-related proteins, especially TDP-43 (ALS), amyloid beta and tau (Alzheimer's disease), α-synuclein (Parkinson's disease, PD), and FUS (frontotemporal dementia, FTD), partially show some characteristics of misfolding prion proteins. Here, MAPT is linked to amyotrophic lateral sclerosis.