The duplication on chromosome 10q11.22 spans two lncRNAs: LINC00842 and LOC105378577; three protein-coding genes: ANTXRL (anthrax toxin receptor-like), ANXA8L1 (annexin A8 like 1), and NPY4R (neuropeptide Y receptor 4); and three transcribed pseudogenes: ANTXRLP1, FAM25BP, and HNRNPA1P33. Each duplication substantially increased esotropia risk [OR 11.1 (95% CI 4.6–25.2), OR 14.16 (95% CI 5.4–38.1), and OR 8.96 (95% CI 5.4–14.9), respectively]. The gene discussed is ANTXRL; the disease is Esotropia.