Korgaonkar et al. (2005) also showed that nucleophosprotein (NPM, also known as B23) was mainly located in the nucleolus and overexpressed in many types of human cancers. Then, the research results of Xu et al. (2014) showed that NPM protein is overexpressed in HCC cells and clarified that NPM played a regulatory role in HCC, and it was worthy of in-depth study. This evidence concerns the gene NPM1 and hepatocellular carcinoma.