DNMT1 and cancer: Screening hits contained a number of substances that are known DNA intercalators, such as doxorubicin, as well as known natural compound DNMT inhibitors, such as epigallocatechinol-3-gallate (Fang et al., 2003), and dietary polyphenols like quercetin, which is known for its anti-cancer effect (Kedhari Sundaram et al., 2019).