IRS2 and Dry skin: IRS2 is important for adequate wound healing (Lima et al., 2012; Manzano-Nunez et al., 2019), which is delayed in elderly skin (Amini-Nik et al., 2022) and loss of EDA is associated with dry skin and eczema (Kowalczyk-Quintas et al., 2015), which are more frequently observed in elderly people (White-Chu and Reddy, 2011).