It was then found that insulin resistance correlates with increased markers of cellular senescence in fat tissue, including adipose tissue β-galactosidase, which is a senescence-linked marker of increased lysosomal activity, as well as increased levels of PAI-1, p53, and cyclin D kinase inhibitors, including p16Ink4a (37, 105, 106). This evidence concerns the gene TP53 and Insulin resistance.