It is hypothesized that cachexia in many types of cancer, including NSCLC, CRC and PANC, is largely mediated via GDF‐15 and that suppression of GDF‐15 may improve cachexia‐related symptoms, including anorexia, leading to unintended weight loss, fatigue and impaired mobility. This evidence concerns the gene GDF15 and non-small cell lung carcinoma.