For example, to help recognize locally aggressive or borderline and overly malignant vascular tumors, some vascular relative biomarkers, such as carcinoembryonic antigen (CEA), human epidermal growth factor receptor 2 (HER 2), vascular endothelial growth factor 165 (VEGF 165), microRNAs [83], can be designed as biomarker nanoprobes of nano-biosensors to accelerated the process of malignant vascular tumors diagnosis, and obtain higher sensitivity and faster screening. The gene discussed is CEACAM5; the disease is vascular neoplasm.