After adjusting the potential confounding factors, including age, BMI, infertility type, the duration of infertility, infertility diagnosis, endometrium thickness, FSH, AMH, TMC, LH surge and E2 on the day of hCG trigger, compared with the follicles ≤ 18.0 mm in diameter group, 19.1–20.0 mm, 20.1–21.0 mm groups were 2.45 or 2.60 times more likely to get LB [adjusted OR = 2.45, 95%CI (1.30–4.61); adjusted OR = 2.60, 95%CI (1.31–5.14)]. The gene discussed is PLOD1; the disease is Infertility.