In this review, we focus on uncovering the relationship of DGAT1 and DGAT2 activities and LD formation in regulating cell proliferation, apoptosis, invasion, the anti-tumor immune response, chemoresistance, and radioresistance of tumor cells, in an attempt to gain a deeper understanding of DGATs and tumor growth, as well as their potential clinical implications for cancer patients. The gene discussed is DGAT2; the disease is neoplasm.