Pre-treatment of MCF-7 cells with PF-06424439 followed by irradiation reduced the transcript levels of CD44 and CD166, two well-recognized CSC markers commonly expressed among primary breast carcinomas, compared to radiation without PF-06424439, suggesting that activity of DGAT2 may be involved in the regulation of CSC [123] (Table 2). The gene discussed is DGAT2; the disease is breast carcinoma.