FOXO3 and neoplasm: The regulation of LD formation in tumor tissues is a complex process entailing numerous biological processes, including inflammation, hypoxia, and acidosis, along with the dysregulation of phosphatase and tensin homolog deleted on chromosome ten (PTEN), kirsten rat sarcoma viral oncogene (KRAS), and forkhead Box Protein O3 (FOXO3)/Sirtuin6 signaling pathways [3, 23–26].