As a marker of LD, PLIN2 was highly expressed in tumor-infiltrating immunocytes of oral squamous cell carcinoma, and higher PLIN2 presentation in the immunocytes effectively induced immune suppression characterized by less infiltration of CD8+ T cells and more CD68+ tumor-associated macrophages (TAMs) and Foxp3+ Tregs, with more immune checkpoint molecules such as CSF1R, homo sapiens galectin 9 (LGALS9), interleukin-10 (IL-10), cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), and T-cell immunoglobulin and ITIM domain proteins (TIGIT). The gene discussed is PLIN2; the disease is neoplasm.