Pre-incubation of DCs with neutralizing antibodies to Msr1 (CD204) for 72 h completely abrogated the effects of tumor explant supernatants on lipid accumulation, whereas the CD36-specific antibody had little effect on lipid accumulation of DCs, indicating that upregulation of Msr1 plays a major role in accumulation of lipids in DCs in cancer. This evidence concerns the gene MSR1 and cancer.