MAPT and Alzheimer disease: Therefore, after showing protective effects in Aβ [25] and phosphorylated tau-bearing mice [26], a logical next step was to elucidate the effect of the BBB-penetrable TNF-α inhibitor in the triple transgenic 3xTg-AD mice that are characterized by the presence of three Aβ and tau mutations (PS1M146V, APPSwe, and tau P301L transgenes) [30].