TNFRSF1A and Alzheimer disease: Given that neuroinflammation appears to be a common pathological process that can initiate and propagate Aβ accumulation and tau tangle formation, the two main prominent neuropathological features of AD, we hypothesized that the BBB-penetrating TfRMAb-TNFR will be therapeutic in a model system that combines both the Aβ and tau pathology.