TNFRSF1A and Alzheimer disease: We measured several phosphorylated tau species, tau phosphorylated at ser202/thr205 (AT8) using immunofluorescence (Additional file 8: Fig. S7 and Additional file 11), and tau phosphorylated at ser199, thr231, ser396, ser404, and ser214 using Nanostring spatial proteomics (Additional file 12: Table S2), and none of these were altered in the hippocampus of the female 3xTg-AD mice following chronic TfRMAb-TNFR dosing.