Notably, the Aβ plaque distribution pattern herein, although low, follows a distribution pattern consistent with other studies in 3xTg-AD mice [35, 39] and mimics the increased susceptibility of the subiculum to AD pathology in humans, and tau pathology follows Aβ pathology in the 3xTg-AD mice [86, 87]. This evidence concerns the gene MAPT and Alzheimer disease.