MAPT and Alzheimer disease: Additionally, tau phosphorylation may be independent of TNF-α and Aβ in the 3xTg-AD mouse model, and is consistent with the work done by Parachikova et al., wherein no change in tau phosphorylation was observed despite a reduction in Aβ and neuroinflammation in 3xTg-AD mice with anti-inflammatory treatment [85].