TNFRSF1A and Alzheimer disease: AT8-positive neurons detected in the subiculum of Tg-Saline 3xTg-AD mice and Tg-TfRMAb-TNFR 3xTg-AD mice are shown in Additional File 8: Fig. S7A, and negligible AT8-positive neurons were found in the WT-Saline mice, as expected.