The 10 most significantly enriched signaling pathways were ‘PPAR signaling pathway’ (FDR: 0.002001573), ‘regulation of lipolysis in adipocytes’ (FDR: 0.069244813), ‘AMPK signaling pathway’ (FDR: 0.069244813), ‘histidine metabolism’ (FDR: 0.069244813), ‘insulin signaling pathway’ (FDR: 0.069244813), ‘neuroactive ligand–receptor interaction’ (FDR: 0.074370072), ‘aldosterone synthesis and secretion’ (FDR: 0.120696471), ‘hepatitis C’ (FDR: 0.120696471), ‘tyrosine metabolism’ (FDR: 0.139915558), and ‘Huntington disease’ (FDR: 0.139915558). The gene discussed is INS; the disease is Huntington disease.