In the present study, we unraveled the inhibitory role of hsa_circ_0004872 in meningioma progression by negatively regulating miR-190a-3p expression, subsequently modulating the phosphatase and tensin homolog deleted on chromosome ten (PTEN)/phosphoinositide-3 kinase (PI3K)/protein kinase B (AKT) pathway. The gene discussed is AKT1; the disease is meningioma.