We observed that the following immune cells were inversely associated with AD risk: CD28 on CD45RA- CD4 not Treg (0.9164, [0.8605–0.9758], 0.0064), CD3 on CM CD8br (0.9224, [0.8685–0.9797], 0.0086), CD4 Treg AC (0.9192, [0.8741–0.9667], 0.0010), HLA DR on CD14- CD16 + monocyte (0.9277, [0.8867–0.9707], 0.0011), SSC-A on HLA DR + CD8br (0.9305, [0.8836-0.9800], 0.0064). The gene discussed is CD28; the disease is Alzheimer disease.