We performed the main analysis using the IVW method(P < 0.01), which revealed that 7 immune cell markers were genetically predicted to be positively associated with AD: CD38 on IgD- CD38br (1.0301, [1.0109–1.0497], 0.0020),HLA DR on CD14 + CD16- monocyte (1.0608, [1.0158–1.1078], 0.0077),HLA DR on CD14 + monocyte (1.0624, [1.0157–1.1111], 0.0083), HVEM on T cell (1.0663, [1.0187–1.1161], 0.0059), IgD on IgD + CD24+ (1.0625, [1.0214–1.1053], 0.0026),IgD on IgD + CD38- unsw mem (1.0651, [1.0138–1.1190], 0.0123),IgD on IgD + CD38br (1.0769, [1.0255–1.1309], 0.0030) (Fig. 2). The gene discussed is CD38; the disease is Alzheimer disease.