Compared with the DR group, the expression of VEGF signaling pathway, Th1 and Th2 cell differentiation and graft-versus-host disease were up-regulated in the DM + MH group; Complement and coagulation cascades, pertussis, neuroactive ligand-receptor down-regulated proteins are mainly enriched in the secretory pathway. The gene discussed is VEGFA; the disease is diabetes mellitus.