Other ligand-receptor pairs revealed by this analysis included TNF-TNFRSF1A sent by medium-SORL1 expressing GAMs, TNFSF12-TNFRSF12A (high-SORL1 GAMs to tumor cells), PDGFB-PDGFRA (medium- and high-SORL1 GAMs to several populations), and THY1-(ITGAM + ITGB2) received by high-SORL1 GAMs (Fig. EV2B). This evidence concerns the gene ITGB2 and neoplasm.