In particular, noncanonical Wnt signaling (WNT5A-FZD3) might promote glioma invasion (Pukrop et al, 2010, 2006) and glutamatergic signaling ((SLC1A3 + GLS)–GRIA2) is known to stimulate tumor cells growth, proliferation, and survival (Prickett and Samuels, 2012). This evidence concerns the gene FZD3 and central nervous system cancer.