In contrast with genetic deletion of Tet2 and Tet3 in Treg cells, which promotes the transdifferentiation of Treg cells into inflammatory ex-Treg cells and the development of autoimmunity (Nakatsukasa et al, 2019; Ohkura et al, 2012; Yue et al, 2019), Fth deletion in Treg cells is not associated with overt autoimmunity (Fig. EV2BG). This evidence concerns the gene TET2 and Autoimmunity.