In WT mice, the percentage of adipocytes with an area larger than 500 μm2 dropped from about 80% to ~30% in iWAT and ~55% in gWAT after tumour implantation, whereas the sizes of cells and lipid droplets in the GPR81−/− tumour-bearing mice were unaffected (Fig. 3d,e). This evidence concerns the gene HCAR1 and neoplasm.