More importantly, UCP1 ablation largely ameliorated LLC tumour-induced cachectic manifestations in the UCP1 knockout mice relative to their wild-type (WT) littermates with similar tumour burden (Fig. 2e–g and Extended Data Fig. 5e–g), suggesting that upregulation of UCP1 is essentially involved in the pathogenesis of cancer cachexia. Here, UCP1 is linked to neoplasm.