About 50% of ARVC patients carry a genetic mutation in desmosome genes and approximately 40% of this patient population carries mutations in PKP2. The heterogeneity of clinical symptoms of ARVC indicates genetic composition, maladaptive remodeling, environmental factors, lifestyle, and other unknown factors of individuals likely affect disease onset and progression. The gene discussed is PKP2; the disease is Arrhythmogenic right ventricular dysplasia.