Pkp2-cKO mice were given a single systemic dose via retro-orbital injection of TN-401 at 3E13 or 6E13 vg/kg one week before tamoxifen induction of cardiac Pkp2 gene deletion (Fig. 7a) and cardiac function and arrhythmias were evaluated at 4 and 9 weeks post induction. The gene discussed is PKP2; the disease is Arrhythmia.