Specifically, in comparison to the consistently low pattern, the HR (95% CI) of T2DM risk with PA trajectories in single peak, double peak, and intense trajectories were 0.78 (0.71–0.85), 0.60 (0.52–0.69), and 0.48 (0.41–0.56) respectively in mod3, fully adjusted for gender, age, ethnicity, education level, income, BMI, smoking status, eGFR, CRP, and medical history. The gene discussed is CRP; the disease is type 2 diabetes mellitus.