IL1B and major depressive disorder: These analyses also show that a significant number of cytokines (including IL1α, IL1β, TNFα, IL2, IL12, IL18) and receptors (sIL-1RA, sIL-6R) are abnormally high in patients suffering from depression [98] and that these disturbances are present in the acute and stability phases, in MDD and BD [99].