Fusions of YAP or TAZ with other genes, including TAZ-CAMTA1, YAP-MAMLD1, YAP-MAML2, YAP-FAM118B, YAP-KMT2A, YAP-TFE3, and YAP-NUTM1, have been reported in various rare tumors such as epithelioid hemangioendothelioma, glioma, supratentorial ependymoma, etc. Similarly, fusion events affecting key components of the Hippo pathway have been found in patients with lung cancer. This evidence concerns the gene WWTR1 and central nervous system cancer.