Chiu et al. demonstrated that vinorelbine-resistant cell lung adenocarcinoma has overexpressed GCS and, after treatment with PDMP or GCS silencing, an accumulation of ceramide and decreased glucosylceramides levels were accompanied by apoptosis with a reduction in anti-apoptotic Bcl-xL protein expression40. Here, BCL2L1 is linked to lung adenocarcinoma.