Our findings revealed a noteworthy and statistically significant positive association between the level of MCM4 expression and the estimated extent of cancer-associated fibroblast infiltration in TCGA tumors from several cancer types, including BRCA-LumA, ACC, ESCA, HNSC(HPV-), LGG, MESO, PAAD, LIHC and THCA. This evidence concerns the gene MCM4 and cancer.