MCM4 and cancer: As shown in Fig. 8A, increased MCM4 expression was significantly associated with unfavorable OS prognosis in several cancer types, including ACC (P = 0.0035), LGG (P = 0.00085), LUAD (P = 0.00092), MESO (P = 0.0031), PAAD (P = 0.013), SARK (P = 0.021), SKCM (P = 0.028), and UVM (P = 0.01).